Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.73 |
| ▸ | HSP90B1 | P14625 | 4/20 | 0.73 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.73 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.73 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.68 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.64 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10456383 | 1.00 | ADORA3 (0.73) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL10455251 | 1.00 | ADORA3 (0.73) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL12359638 | 1.00 | ADORA3 (0.73) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL13473622 | 0.88 | ADORA3 (0.73) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL19423461 | 0.87 | ADORA3 (0.77) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL15462103 | 0.87 | ADORA3 (0.77) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL8102669 | 0.85 | ADORA3 (1.00) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL30101819 | 0.85 | ADORA3 (1.00) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL14532997 | 0.84 | AHCY (0.69) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 | |
| SCHEMBL10459063 | 0.84 | ADORA2A (0.69) | ADORA3ADORA2AHSP90B1ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109646-A1 | METHOD FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION WITH AN ADENOSINE DERIVATIVE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2013-05-02 | — | — | US | disclosed |
| US-20130109646-A1 | METHOD FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION WITH AN ADENOSINE DERIVATIVE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2013-05-02 | — | — | US | disclosed |
| EP-1778712-B1 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | Univ Virginia Patent Found (US) | 2013-01-30 | — | — | EP | disclosed |
| US-8293720-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293720-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8058259-B2 | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-11-15 | — | — | US | disclosed |
| US-8058259-B2 | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-11-15 | — | — | US | disclosed |
| US-7989431-B2 | 4-{3-[6-Amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-cyclohexanecarboxylic acid methyl ester; for inflammation, such as organ, tissue or cell transplantation, angioplasty (PCTA), inflammation following ischemia/reperfusion, or grafting | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-08-02 | — | — | US | disclosed |
| US-20110136755-A1 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2266994-A1 | 2-propynyl adenosine analgos with modified 5'-ribose groups having A2A agonist activity | University Of Virginia Patent Foundation (US) | 2010-12-29 | — | — | EP | disclosed |
| US-7605143-B2 | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-10-20 | — | — | US | disclosed |
| US-20090253647-A1 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION AND ADENOSINE THERAPEUTICS, L.L.C. | 2009-10-08 | — | — | US | disclosed |
| WO-2009082720-A2 | SUBSTITUTED 4-{3-[6-AMINO-9-(3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-2-YL]-PROP-2-YNYL}-PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | PGX HEALTH, LLC (US) | 2009-07-02 | — | — | WO | disclosed |
| US-20090162282-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-06-25 | — | — | US | disclosed |
| US-20090162282-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-06-25 | — | — | US | disclosed |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | PGXHEALTH, LLC (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | PGXHEALTH, LLC (US) | 2009-06-25 | — | — | US | disclosed |
| EP-1778712-A2 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060040888-A1 | 2-propynyl adenosine analogs with modifed 5'-ribose groups having A2A agonist activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-02-23 | — | — | US | disclosed |
| WO-2006015357-A2 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109646-A1 | METHOD FOR TREATING GLAUCOMA OR OCULAR HYPERTENSION WITH AN ADENOSINE DERIVATIVE | ADORA1, ADORA3, ADORA2A | ADORA3 2/4885ADORA2A 3/4885HSP90B1 3053/4885 |
| US-20090162292-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885ADORA2A 1/4885HSP90B1 2759/4885 |
| US-20090162282-A1 | SUBSTITUTED 4--PIPERIDINE-1-CARBOXYLIC ACID ESTERS AS A2AR AGONISTS | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885ADORA2A 1/4885HSP90B1 2759/4885 |
| US-20090253647-A1 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885ADORA2A 1/4885HSP90B1 4637/4885 |
| US-20110136755-A1 | 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885ADORA2A 1/4885HSP90B1 4637/4885 |
| US-20060040888-A1 | 2-propynyl adenosine analogs with modifed 5'-ribose groups having A2A agonist activity | ADORA2A, ADORA3, ADORA1 | ADORA3 2/4885ADORA2A 1/4885HSP90B1 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.