Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23147126 | 0.86 | KMT2A (0.60) | ALDH1A1KDM4ELMNAHSD17B10GABRA1 | |
| SCHEMBL19511938 | 0.85 | KDM4E (0.54) | ALDH1A1KDM4ELMNAHSD17B10MEN1 | |
| SCHEMBL28430420 | 0.83 | KDM4E (0.63) | ALDH1A1KDM4ELMNAHSD17B10GABRA1 | |
| SCHEMBL198437 | 0.82 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAHSD17B10GABRA1 | |
| SCHEMBL19511981 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAHSD17B10GABRA1 | |
| SCHEMBL18044628 | 0.80 | LMNA (0.59) | ALDH1A1KDM4ELMNAGABRA1GABRG2 | |
| SCHEMBL1883282 | 0.77 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNAHSD17B10KMT2A | |
| SCHEMBL28433852 | 0.77 | HSD17B10 (0.66) | ALDH1A1KDM4ELMNAHSD17B10MEN1 | |
| SCHEMBL1136978 | 0.75 | ALDH1A1 (0.60) | ALDH1A1KDM4ELMNAHSD17B10GABRA1 | |
| SCHEMBL1885385 | 0.75 | GABRG2 (0.56) | ALDH1A1KDM4ELMNAGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239147-B1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2019-08-28 | — | — | EP | disclosed |
| US-10208034-B2 | Quinoline derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-02-19 | — | — | US | disclosed |
| US-20170349583-A1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-12-07 | — | — | US | disclosed |
| EP-3239147-A1 | QUINOLINE DERIVATIVE | Ono Pharmaceutical Co., Ltd. (JP) | 2017-11-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349583-A1 | QUINOLINE DERIVATIVE | FLT3, AXL, ABL1 | ALDH1A1 3586/4885KDM4E 972/4885LMNA 4461/4885 |
| US-10208034-B2 | Quinoline derivative | FLT3, AXL, ABL1 | ALDH1A1 3586/4885KDM4E 972/4885LMNA 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.