Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 6/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.44 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.43 |
| ▸ | DVL1 | O14640 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19512123 | 0.92 | KDM4E (0.49) | KDM4EPKMPLK1PLK3AKR1C2 | |
| SCHEMBL19512047 | 0.91 | KDM4E (0.62) | KDM4EPKMPLK1PLK3METAP2 | |
| SCHEMBL19512000 | 0.89 | AKR1C2 (0.56) | KDM4EPKMPLK1PLK3AKR1C2 | |
| SCHEMBL19512003 | 0.84 | KDM4E (0.52) | KDM4EPKMTRPV1LTC4SMAPT | |
| SCHEMBL19511998 | 0.83 | ACLY (0.56) | KDM4EPLK1PLK3AKR1C2AKR1C1 | |
| SCHEMBL19511945 | 0.82 | KDM4E (0.54) | KDM4EPKMPLK1PLK3AKR1C2 | |
| SCHEMBL19512112 | 0.80 | HCAR2 (0.56) | KDM4EPKMAKR1C2AKR1C1TRPV1 | |
| SCHEMBL19512111 | 0.80 | KDM4E (0.49) | KDM4EPKMTRPV1LTC4SMAPT | |
| SCHEMBL19512020 | 0.79 | AKR1C2 (0.46) | KDM4EAKR1C2AKR1C1TRPV1POLB | |
| SCHEMBL14075292 | 0.76 | KDM4E (0.62) | KDM4EPKMLTC4SDVL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2018-02-08 | — | — | US | claimed |
| EP-3239133-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2017-11-01 | — | — | EP | claimed |
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2018-02-08 | — | — | US | disclosed |
| EP-3239133-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2017-11-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | NCS1, CACNA1B, ORAI1 | KDM4E 659/4885PKM 974/4885PLK1 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.