Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | DVL1 | O14640 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19512033 | 0.89 | SERPINE1 (0.49) | KDM4EPKMSERPINE1NR1H4TRPV1 | |
| SCHEMBL19512005 | 0.84 | KDM4E (0.57) | KDM4EPKMLTC4STRPV1DVL1 | |
| SCHEMBL19512111 | 0.80 | KDM4E (0.49) | KDM4EPKMLTC4STRPV1DVL1 | |
| SCHEMBL19512038 | 0.79 | HCAR2 (0.53) | KDM4EPKMSERPINE1NR1H4TRPV1 | |
| SCHEMBL19512025 | 0.79 | KDM4E (0.44) | KDM4ETRPV1NLRP3ALDH1A1KCNQ2 | |
| SCHEMBL14075292 | 0.77 | KDM4E (0.62) | KDM4EPKMLTC4SNLRP3DVL1 | |
| SCHEMBL19512124 | 0.76 | ACLY (0.60) | KDM4EPKMSERPINE1TRPV1ALDH1A1 | |
| SCHEMBL22080099 | 0.75 | VNN1 (0.43) | KDM4ETRPV1NLRP3ALDH1A1KCNQ2 | |
| SCHEMBL19512123 | 0.75 | KDM4E (0.49) | KDM4EPKMTRPV1ALDH1A1KCNQ2 | |
| SCHEMBL19512047 | 0.74 | KDM4E (0.62) | KDM4EPKMTRPV1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2018-02-08 | — | — | US | claimed |
| EP-3239133-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2017-11-01 | — | — | EP | claimed |
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2018-02-08 | — | — | US | disclosed |
| EP-3239133-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | Consejo Superior de Investigaciones Cientificas (CSIC) (ES) | 2017-11-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037538-A1 | DREAM NEURONAL CALCIUM SENSOR-MODULATING COMPOUNDS, AND THERAPEUTIC USES THEREOF | NCS1, CACNA1B, ORAI1 | KDM4E 659/4885PKM 974/4885SERPINE1 4494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.