Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sitokiren. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN known ✓ | P00797 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sitokiren SCHEMBL16471589 | 1.00 | REN (1.00) | REN | |
| Sitokiren SCHEMBL16471588 | 1.00 | REN (1.00) | REN | |
| Sitokiren SCHEMBL26960855 | 1.00 | REN (1.00) | REN | |
| Sitokiren SCHEMBL29492575 | 1.00 | REN (1.00) | REN | |
| Sitokiren SCHEMBL19512224 | 1.00 | REN (1.00) | REN | |
| SCHEMBL17012941 | 0.94 | REN (0.89) | REN | |
| SCHEMBL15418065 | 0.94 | REN (0.88) | REN | |
| SCHEMBL20548988 | 0.94 | REN (0.88) | REN | |
| SCHEMBL19512220 | 0.94 | REN (0.88) | REN | |
| SCHEMBL17550610 | 0.94 | REN (0.88) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687518-B1 | NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-11-01 | — | — | EP | claimed |
| EP-4209218-A1 | APPLICATION OF NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2023-07-12 | — | — | EP | disclosed |
| WO-2022048618-A1 | METHODS TO TREAT INFLAMMATORY BOWEL DISEASE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2022-03-10 | — | — | WO | disclosed |
| WO-2022047730-A1 | METHODS TO TREAT INFLAMMATORY BOWEL DISEASE | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2022-03-10 | — | — | WO | disclosed |