Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9130883 | 0.76 | NPC1 (0.58) | ALDH1A1KDM4ETP53P2RX7RAB9A | |
| SCHEMBL29136551 | 0.76 | P2RX7 (0.51) | ALDH1A1KDM4ETP53P2RX7RAB9A | |
| SCHEMBL19322921 | 0.75 | CYP3A4 (0.60) | ALDH1A1KDM4ETP53P2RX7RAB9A | |
| SCHEMBL27532876 | 0.72 | KDM4E (0.51) | ALDH1A1KDM4EP2RX7RAB9ANPC1 | |
| SCHEMBL19318495 | 0.71 | TSHR (0.58) | ALDH1A1KDM4ETP53P2RX7RAB9A | |
| SCHEMBL10001058 | 0.68 | CYP1A1 (0.63) | ALDH1A1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL17745504 | 0.68 | CYP1A1 (0.63) | ALDH1A1RAB9ANPC1LMNAMEN1 | |
| SCHEMBL9551726 | 0.68 | — | — | |
| SCHEMBL14164232 | 0.68 | ALDH1A1 (0.71) | ALDH1A1KDM4ETP53RAB9ANPC1 | |
| SCHEMBL17667093 | 0.68 | ALDH1A1 (1.00) | ALDH1A1KDM4ETP53RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2736887-B1 | HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS INC (US) | 2017-10-18 | — | — | EP | disclosed |