Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19322921 | 0.83 | CYP3A4 (0.60) | NPC1RAB9APKMP2RX7NAMPT | |
| SCHEMBL27532876 | 0.80 | KDM4E (0.51) | NPC1RAB9APKMP2RX7NAMPT | |
| SCHEMBL29136551 | 0.80 | P2RX7 (0.51) | NPC1RAB9APKMP2RX7NAMPT | |
| SCHEMBL967245 | 0.80 | RAB9A (0.72) | NPC1RAB9APKMNAMPTALDH1A1 | |
| SCHEMBL11213715 | 0.80 | RAB9A (0.72) | NPC1RAB9APKMNAMPTALDH1A1 | |
| SCHEMBL19318495 | 0.79 | TSHR (0.58) | NPC1RAB9APKMP2RX7NAMPT | |
| SCHEMBL4718965 | 0.77 | ALDH1A1 (0.57) | NPC1RAB9APKMNAMPTALDH1A1 | |
| SCHEMBL3724442 | 0.77 | ALOX5 (0.67) | ALDH1A1LMNAKDM4EGAATP53 | |
| SCHEMBL19519086 | 0.76 | ALDH1A1 (0.51) | NPC1RAB9APKMP2RX7NAMPT | |
| SCHEMBL27706331 | 0.76 | NAMPT (0.60) | NPC1RAB9APKMP2RX7NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102656159-A | Cgrp receptor antagonists | BRISTOL MYERS SQUIBB CO | 2012-09-05 | — | — | CN | claimed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | claimed |
| CN-106517049-B | 360 ° of large parts turnover devices of one kind and its working method | 江苏建筑职业技术学院 | 2018-07-20 | — | — | CN | disclosed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-102656159-A | Cgrp receptor antagonists | BRISTOL MYERS SQUIBB CO | 2012-09-05 | — | — | CN | disclosed |
| CN-101855222-A | Imidazol (1,2-A)pyridines and related compounds with activity at cannabinoid CB2 receptors | GE HEALTHCARE LTD | 2010-10-06 | — | — | CN | disclosed |
| CN-101730691-A | Nitrogen-containing aromatic six-membered ring derivatives and drugs containing the same | ASUBIO PHARMA CO LTD | 2010-06-09 | — | — | CN | disclosed |
| CN-100579979-C | 7-phenylpyrazolopyridine compounds | EISAI R&D MAN CO LTD | 2010-01-13 | — | — | CN | disclosed |
| CN-101081850-A | 7-phenylpyrazolopyridine compounds | EISAI CO LTD (JP) | 2007-12-05 | — | — | CN | disclosed |
| CN-101081853-A | 4- (hydroxymethyl) -2, 6-dimethoxyphenylboronic acid compound | EISAI CO LTD (JP) | 2007-12-05 | — | — | CN | disclosed |
| CN-1705665-A | 7-phenylpyrazolopyridine compounds | EISAI CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |