Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 10/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 1.00 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR1E | P28566 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19537625 | 0.91 | TMEM97 (0.83) | TMEM97SIGMAR1CXCR3HTR1AADRA2A | |
| SCHEMBL17114684 | 0.89 | TMEM97 (0.80) | TMEM97SIGMAR1CXCR3PTGDR2NPC1 | |
| SCHEMBL17114834 | 0.88 | TMEM97 (0.79) | TMEM97SIGMAR1CXCR3HTR1ASLC6A4 | |
| SCHEMBL19521511 | 0.87 | TMEM97 (1.00) | TMEM97SIGMAR1CXCR3HTR1AHRH2 | |
| SCHEMBL19521533 | 0.86 | SIGMAR1 (1.00) | TMEM97SIGMAR1CXCR3HTR1AADRA2A | |
| SCHEMBL17114743 | 0.83 | CXCR3 (1.00) | TMEM97SIGMAR1CXCR3PTGDR2 | |
| SCHEMBL17114846 | 0.83 | TMEM97 (0.71) | TMEM97SIGMAR1CXCR3HTR1AADRA2A | |
| SCHEMBL17114843 | 0.83 | TMEM97 (0.71) | TMEM97SIGMAR1CXCR3HTR1AADRA2A | |
| SCHEMBL18729961 | 0.82 | TMEM97 (0.69) | TMEM97SIGMAR1CXCR3PTGDR2 | |
| SCHEMBL18729964 | 0.82 | TMEM97 (0.69) | TMEM97SIGMAR1CXCR3PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300903-A1 | SIGMA RECEPTOR BINDERS | UNIV TEXAS (US) | 2021-09-30 | — | — | US | disclosed |
| US-20210300903-A1 | SIGMA RECEPTOR BINDERS | UNIV TEXAS (US) | 2021-09-30 | — | — | US | disclosed |
| US-10954217-B2 | Sigma receptor binders | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-03-23 | — | — | US | disclosed |
| US-10954217-B2 | Sigma receptor binders | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-03-23 | — | — | US | disclosed |
| US-20190177301-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
| US-20190177301-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2019-06-13 | — | — | US | disclosed |
| WO-2017190109-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-11-02 | — | — | WO | disclosed |
| WO-2017190109-A1 | SIGMA RECEPTOR BINDERS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954217-B2 | Sigma receptor binders | SIGMAR1, OPRK1, OPRL1 | TMEM97 6/4885SIGMAR1 1/4885CXCR3 393/4885 |
| US-20190177301-A1 | SIGMA RECEPTOR BINDERS | SIGMAR1, OPRK1, OPRL1 | TMEM97 6/4885SIGMAR1 1/4885CXCR3 393/4885 |
| US-20210300903-A1 | SIGMA RECEPTOR BINDERS | SIGMAR1, OPRK1, OPRL1 | TMEM97 6/4885SIGMAR1 1/4885CXCR3 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.