Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683749 | 0.91 | YTHDC1 (0.34) | KDM4CKMT2AHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL17670496 | 0.91 | ALDH1A1 (0.40) | KDM4CMEN1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL17670506 | 0.86 | KDM4C (0.40) | KDM4CMEN1HCRTR1KMT2APSEN1 | |
| SCHEMBL17544777 | 0.83 | HSP90AA1 (0.36) | MEN1KMT2ABRD4HSP90AA1HSP90B1 | |
| SCHEMBL17670343 | 0.83 | L3MBTL1 (0.41) | — | |
| SCHEMBL17670498 | 0.83 | HSP90B1 (0.40) | MEN1KMT2AHSP90B1 | |
| SCHEMBL17670434 | 0.80 | KLKB1 (0.39) | HSP90AA1HSP90AB1HSP90B1HDAC1 | |
| SCHEMBL17670467 | 0.79 | ADORA2A (0.34) | MEN1KMT2A | |
| SCHEMBL17549907 | 0.79 | BRD4 (0.34) | MEN1KMT2ABRD4 | |
| SCHEMBL17670471 | 0.79 | P2RY14 (0.38) | MEN1KMT2AP2RY14HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |