Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570617 | 0.80 | SCN8A (0.49) | SCN8ASCN10ASLC6A4NPSR1FFAR4 | |
| SCHEMBL18570710 | 0.77 | SCN8A (0.45) | SCN8ASCN10ASLC6A2SLC6A4NPSR1 | |
| SCHEMBL18570698 | 0.76 | SCN8A (0.47) | SCN8ASCN10AEPAS1ALDH1A1AR | |
| SCHEMBL6500895 | 0.76 | GPR3 (0.42) | SLC6A2EPAS1CHRM2CHRM1CHRM3 | |
| SCHEMBL1985337 | 0.75 | TUBB1 (0.51) | ALDH1A1CYP1A2TUBB1 | |
| SCHEMBL17822065 | 0.75 | GPR3 (0.41) | SLC6A2FFAR4CHRM2CHRM1CHRM3 | |
| SCHEMBL18570545 | 0.74 | SCN8A (0.52) | SCN8ASCN10ANPSR1ALDH1A1LMNA | |
| SCHEMBL18570714 | 0.73 | SCN10A (0.50) | SCN8ASCN10AEPAS1ALDH1A1LMNA | |
| SCHEMBL22809756 | 0.73 | SCN8A (0.46) | SCN8ASCN10ANPSR1EPAS1ALDH1A1 | |
| SCHEMBL2824893 | 0.73 | GPR3 (0.42) | SLC6A2FFAR4FFAR1SCN9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2017-11-01 | — | — | EP | disclosed |