Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.56 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9367885 | 0.90 | PTGER4 (0.51) | SCN8ASCN10APTGER4PTGER2SMN1; SMN2 | |
| SCHEMBL4112011 | 0.87 | SCN8A (0.55) | SCN8ASCN10ACTNNB1HTR2ASLC6A4 | |
| SCHEMBL29250430 | 0.84 | SCN8A (0.54) | SCN8ASCN10ACTNNB1HTR2ASLC6A4 | |
| SCHEMBL27549107 | 0.84 | CTNNB1 (0.70) | SCN8ASCN10ACTNNB1HTR2ASLC6A4 | |
| SCHEMBL29679671 | 0.83 | CTNNB1 (0.67) | CTNNB1TSPOMEN1KMT2AL3MBTL1 | |
| SCHEMBL3179214 | 0.83 | CTNNB1 (0.67) | CTNNB1TSPOMEN1KMT2AL3MBTL1 | |
| SCHEMBL24631538 | 0.83 | KMT2A (0.50) | SCN8ASCN10ACTNNB1SLC6A4KMT2A | |
| SCHEMBL30748241 | 0.83 | KMT2A (0.50) | SCN8ASCN10ACTNNB1SLC6A4KMT2A | |
| SCHEMBL19524204 | 0.81 | SCN8A (0.53) | SCN8ASCN10ACTNNB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8136102 | 0.81 | CTNNB1 (0.65) | CTNNB1TSPOMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2017-11-01 | — | — | EP | disclosed |