Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 8/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19527732 | 0.83 | NPC1 (0.49) | NPC1RAB9AEGFRSYKGRM5 | |
| SCHEMBL19527678 | 0.81 | NPC1 (0.47) | NPC1RAB9AEGFRAAK1SYK | |
| SCHEMBL19527651 | 0.81 | NPC1 (0.47) | NPC1RAB9AEGFRITKSYK | |
| SCHEMBL19527814 | 0.81 | EGFR (0.51) | NPC1RAB9AEGFRITKSYK | |
| SCHEMBL19527785 | 0.80 | NPC1 (0.47) | NPC1RAB9AEGFRITKSYK | |
| SCHEMBL19527760 | 0.78 | EGFR (0.49) | NPC1RAB9AEGFRITKSYK | |
| SCHEMBL18995121 | 0.77 | NPC1 (0.47) | NPC1RAB9AGRM5MAPT | |
| SCHEMBL15322162 | 0.73 | EGFR (0.41) | EGFRITK | |
| SCHEMBL18994991 | 0.69 | NPC1 (0.47) | NPC1RAB9AEGFRITKSYK | |
| SCHEMBL29430454 | 0.69 | PTK2 (0.50) | EGFRITKSYKMAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833889-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2017-11-01 | — | — | EP | disclosed |