Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 16/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18995012 | 0.85 | BCL6 (0.43) | — | |
| SCHEMBL19527725 | 0.85 | TNIK (0.39) | TBK1IKBKEMAPTJAK2 | |
| SCHEMBL18995069 | 0.83 | ULK1 (0.44) | JAK2 | |
| SCHEMBL19527748 | 0.83 | TBK1 (0.37) | NPC1RAB9ATBK1GRM5 | |
| SCHEMBL19836644 | 0.82 | NPC1 (0.49) | NPC1RAB9ATBK1IKBKEMAPT | |
| SCHEMBL19527732 | 0.79 | NPC1 (0.49) | NPC1RAB9AGRM5MAPT | |
| SCHEMBL19527665 | 0.78 | TBK1 (0.38) | NPC1RAB9ATBK1GRM5IKBKE | |
| SCHEMBL19527678 | 0.77 | NPC1 (0.47) | NPC1RAB9AGRM5MAPT | |
| SCHEMBL19527651 | 0.77 | NPC1 (0.47) | NPC1RAB9ATBK1GRM5MAPT | |
| SCHEMBL18994991 | 0.77 | NPC1 (0.47) | NPC1RAB9ATBK1GRM5IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682976-B2 | Protein kinase C inhibitors and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2017-06-20 | — | — | US | disclosed |