Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 18/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684381 | 0.73 | HSD11B1 (0.66) | HSD11B1 | |
| SCHEMBL16666728 | 0.72 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL16684444 | 0.72 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL7093602 | 0.64 | FAAH (0.72) | KDM4EALDH1A1 | |
| SCHEMBL1150351 | 0.62 | USP2 (0.52) | DDB1CRBNHSD11B1KDM4EALDH1A1 | |
| SCHEMBL16684382 | 0.62 | HSD11B1 (0.71) | HSD11B1 | |
| SCHEMBL31396745 | 0.62 | SMYD3 (0.58) | DDB1CRBNALDH1A1 | |
| SCHEMBL3646204 | 0.62 | SMYD3 (0.61) | DDB1CRBNKDM4E | |
| SCHEMBL27821167 | 0.62 | KMT2A (0.72) | DDB1CRBN | |
| SCHEMBL2208370 | 0.61 | PBRM1 (0.55) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865664-B1 | NOVEL COMPOUND HAVING ABILITY TO INHIBIT 11B-HSD1 ENZYME OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT | BAMICHEM CO LTD (KR) | 2017-11-01 | — | — | EP | disclosed |