Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27551098 | 0.77 | NPC1 (0.46) | LMNATDP1GAASMN1; SMN2HCRTR1 | |
| SCHEMBL2866599 | 0.76 | GAA (0.51) | LMNATDP1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL198066 | 0.75 | SMN1; SMN2 (0.42) | LMNATDP1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL36575 | 0.71 | — | — | |
| SCHEMBL29842244 | 0.71 | LMNA (0.46) | LMNATDP1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL27816158 | 0.71 | LMNA (0.46) | LMNATDP1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL11367102 | 0.70 | CYP1A1 (0.46) | LMNATDP1GAASMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL1007846 | 0.70 | — | — | |
| SCHEMBL5476182 | 0.69 | LMNA (0.41) | LMNATDP1GAASMN1; SMN2CYP3A4 | |
| SCHEMBL28219132 | 0.69 | HTR2C (0.45) | LMNATDP1GAASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074387-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-11-08 | — | — | EP | disclosed |