Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.49 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.49 |
| ▸ | UBA1 | P22314 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | RNMT | O43148 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 3/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25296572 | 0.87 | CA2 (0.62) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297682 | 0.81 | CA2 (0.69) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297489 | 0.80 | NAE1 (0.68) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297466 | 0.74 | CA2 (0.68) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297708 | 0.73 | CA2 (0.74) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297537 | 0.73 | CA2 (0.66) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297582 | 0.72 | CA2 (0.65) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297513 | 0.72 | CA2 (0.68) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL18297717 | 0.71 | CA2 (0.67) | CA2NAE1UBA3UBA1SAE1 | |
| SCHEMBL20142034 | 0.71 | ATG7 (0.61) | ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103802-B1 | NOVEL PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME, ESPECIALLY AGENT FOR PREVENTION AND/OR TREATMENT OF TUMORS ETC BASED ON NAE INHIBITORY EFFECT | TAIHO PHARMACEUTICAL CO LTD (JP) | 2017-11-08 | — | — | EP | disclosed |