Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554219 | 0.89 | AKR1C4 (0.48) | NPC1RAB9ALMNACYP1A2CYP3A4 | |
| SCHEMBL19570245 | 0.88 | NPC1 (0.49) | NPC1RAB9ALMNACYP1A2CYP3A4 | |
| SCHEMBL19554185 | 0.83 | RAB9A (0.44) | NPC1RAB9ALMNAGAASMN1; SMN2 | |
| SCHEMBL19554262 | 0.83 | KCNK2 (0.44) | NPC1RAB9ACYP1A2CYP3A4AKR1C2 | |
| SCHEMBL19575809 | 0.81 | KCNK2 (0.42) | MEN1KMT2AKDM4E | |
| SCHEMBL19554194 | 0.81 | PDE5A (0.39) | NPC1AKR1C2AKR1C1 | |
| SCHEMBL19554177 | 0.81 | KCNK2 (0.44) | NPC1RAB9ALMNAGAASMN1; SMN2 | |
| SCHEMBL19554226 | 0.79 | KCNK2 (0.42) | LMNASMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL19554122 | 0.79 | AKR1C4 (0.61) | NPC1RAB9ACYP1A2CYP3A4AKR1C2 | |
| SCHEMBL19554333 | 0.79 | AKR1C4 (0.56) | NPC1RAB9ALMNAAKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |