Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 4/20 | 0.38 |
| ▸ | BCL9 | O00512 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554158 | 0.91 | SLC16A3 (0.46) | PDE5APDE1APDE1BPDE1CSLC16A3 | |
| SCHEMBL19554254 | 0.89 | HDAC3 (0.40) | GPR6GRM5 | |
| SCHEMBL19554182 | 0.88 | NPC1 (0.42) | BCL9CTNNB1CA12CA1CA7 | |
| SCHEMBL19554215 | 0.86 | SMN1; SMN2 (0.44) | BCL9CTNNB1CA12CA1CA7 | |
| SCHEMBL19554219 | 0.84 | AKR1C4 (0.48) | CA12CA1CA7NPC1AKR1C4 | |
| SCHEMBL19554178 | 0.81 | NPC1 (0.52) | NPC1AKR1C2AKR1C1 | |
| SCHEMBL19554262 | 0.80 | KCNK2 (0.44) | SLC16A3KCNK2DHODHNPC1AKR1C2 | |
| SCHEMBL19554171 | 0.79 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CAKR1C4 | |
| SCHEMBL19575809 | 0.78 | KCNK2 (0.42) | SLC16A3KCNK2DHODH | |
| SCHEMBL19554185 | 0.78 | RAB9A (0.44) | SLC16A3KCNK2DHODHNPC1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |