Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 13/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.53 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554217 | 0.90 | SERPINE1 (0.58) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554134 | 0.83 | SERPINE1 (0.68) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554183 | 0.78 | SERPINE1 (0.52) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554229 | 0.78 | SERPINE1 (0.61) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554148 | 0.78 | DHODH (0.70) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6349535 | 0.76 | SERPINE1 (0.74) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6358123 | 0.76 | SERPINE1 (0.89) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6351321 | 0.76 | SERPINE1 (0.89) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554199 | 0.75 | SERPINE1 (0.57) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL19554129 | 0.75 | SERPINE1 (0.66) | SERPINE1AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |