Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TPH1 | P17752 | 2/20 | 0.36 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555467 | 0.93 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555501 | 0.93 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19555512 | 0.93 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19569599 | 0.88 | ATF4 (0.59) | ATF4KDM4EALDH1A1 | |
| SCHEMBL30025762 | 0.88 | ATF4 (0.59) | ATF4KDM4EALDH1A1 | |
| SCHEMBL19555514 | 0.88 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555487 | 0.87 | ATF4 (0.52) | ATF4 | |
| SCHEMBL19555477 | 0.86 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555458 | 0.84 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555457 | 0.82 | ATF4 (0.43) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |