Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 19/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569599 | 1.00 | ATF4 (0.59) | ATF4KDM4EALDH1A1 | |
| SCHEMBL30025819 | 0.90 | ATF4 (0.61) | ATF4 | |
| SCHEMBL19569426 | 0.90 | ATF4 (0.61) | ATF4 | |
| SCHEMBL20974048 | 0.90 | ATF4 (0.61) | ATF4 | |
| SCHEMBL19569432 | 0.90 | ATF4 (0.61) | ATF4 | |
| SCHEMBL30025683 | 0.90 | ATF4 (0.61) | ATF4 | |
| SCHEMBL19569221 | 0.89 | ATF4 (0.59) | ATF4 | |
| SCHEMBL30025316 | 0.89 | ATF4 (0.59) | ATF4 | |
| SCHEMBL19555455 | 0.88 | ATF4 (0.46) | ATF4KDM4EALDH1A1 | |
| SCHEMBL19577549 | 0.86 | ATF4 (0.55) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| CN-115947681-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-109641844-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-01 | — | — | CN | disclosed |