Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 16/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555487 | 0.89 | ATF4 (0.52) | ATF4 | |
| SCHEMBL19555503 | 0.85 | ATF4 (0.41) | ATF4 | |
| SCHEMBL19569751 | 0.85 | ATF4 (0.60) | ATF4 | |
| SCHEMBL19555512 | 0.82 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555467 | 0.82 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555501 | 0.82 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19555455 | 0.82 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19555488 | 0.81 | ATF4 (0.38) | ATF4IDO1 | |
| SCHEMBL19555511 | 0.81 | ATF4 (0.42) | ATF4 | |
| SCHEMBL19555514 | 0.81 | ATF4 (0.47) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |