Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555478 | 0.91 | ATF4 (0.37) | ATF4IDO1MAOBHRH1CCR3 | |
| SCHEMBL30026036 | 0.83 | ATF4 (0.54) | ATF4ALDH1A1 | |
| SCHEMBL19569208 | 0.83 | ATF4 (0.54) | ATF4ALDH1A1 | |
| SCHEMBL19555498 | 0.83 | MAOB (0.39) | ATF4MAOBHRH1CCR3 | |
| SCHEMBL19555452 | 0.82 | ATF4 (0.36) | ATF4HRH1CCR3HPGD | |
| SCHEMBL19555457 | 0.81 | ATF4 (0.43) | ATF4IDO1 | |
| SCHEMBL19569444 | 0.77 | ATF4 (0.64) | ATF4 | |
| SCHEMBL19555508 | 0.76 | ATF4 (0.42) | ATF4 | |
| SCHEMBL19555474 | 0.76 | CNR1 (0.34) | ATF4ALDH1A1 | |
| SCHEMBL19555511 | 0.76 | ATF4 (0.42) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452448-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |