Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of N-Phenylbenzamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 known ✓ | O60674 | 1/20 | 0.66 |
| ▸ | TYK2 known ✓ | P29597 | 1/20 | 0.66 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.71 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.70 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.63 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Phenylbenzamide SCHEMBL3681194 | 1.00 | SIRT1 (0.74) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| SCHEMBL24202631 | 0.93 | SIRT1 (0.83) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL31966 | 0.93 | SIRT1 (0.83) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL5402750 | 0.93 | SIRT1 (0.83) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL11337922 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL7787063 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL11334226 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL6718614 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL23248037 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 | |
| N-Phenylbenzamide SCHEMBL8372230 | 0.91 | SIRT1 (0.80) | SIRT1PTPN1KCNK3KCNK9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110129917-A1 | CELL ISOLATION METHOD | Yanagita, Tomotaka (JP) | 2011-06-02 | — | — | US | disclosed |