Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19011087 | 0.82 | MITF (0.32) | MITF | |
| SCHEMBL47577 | 0.82 | MITF (0.36) | MITF | |
| SCHEMBL2152164 | 0.79 | TDP1 (0.43) | MAPT | |
| SCHEMBL23890860 | 0.77 | AR (0.30) | — | |
| SCHEMBL13891783 | 0.77 | ALOX5 (0.31) | — | |
| SCHEMBL19558728 | 0.74 | CYP2E1 (0.37) | NPC1MAPTRAB9A | |
| SCHEMBL418112 | 0.71 | MITF (0.33) | MITF | |
| SCHEMBL18869524 | 0.71 | CYP2E1 (0.43) | MAPT | |
| SCHEMBL20121971 | 0.70 | MITF (0.32) | MITF | |
| SCHEMBL22342802 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9808466-B2 | Macrocyclic compounds as protein kinase inhibitors | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III | 2017-11-07 | — | — | US | disclosed |