Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28895975 | 0.82 | TDP1 (0.43) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL19558652 | 0.79 | MITF (0.33) | MAPT | |
| SCHEMBL2152169 | 0.77 | TDP1 (0.39) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL23890860 | 0.76 | AR (0.30) | — | |
| SCHEMBL13891783 | 0.76 | ALOX5 (0.31) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL420157 | 0.75 | TDP1 (0.53) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL19681462 | 0.75 | TDP1 (0.53) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL2151779 | 0.75 | HTR1A (0.38) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL7949905 | 0.75 | MAPT (0.39) | TDP1HTR1AHTR7HTR6MEN1 | |
| SCHEMBL20850253 | 0.74 | TDP1 (0.40) | TDP1HTR1AHTR7HTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2340021-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. Hoffmann-La Roche AG (CH) | 2011-07-06 | — | — | EP | disclosed |
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |