Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559734 | 0.77 | PPARG (0.36) | PPARGCYP3A4RXRAHRH3KMT2A | |
| SCHEMBL19559762 | 0.76 | PPARG (0.45) | PPARGCYP3A4RXRAALOX15POLB | |
| SCHEMBL18323953 | 0.75 | PPARG (0.66) | PPARGCYP3A4RXRAHRH3KMT2A | |
| SCHEMBL19559710 | 0.75 | NPC1 (0.47) | PPARGKMT2AMEN1KDM4CMAPT | |
| SCHEMBL19559801 | 0.75 | PPARG (0.46) | PPARGCYP3A4RXRAHRH3ALOX15 | |
| SCHEMBL19559802 | 0.71 | PPARG (0.41) | PPARGCYP3A4RXRAALDH1A1L3MBTL1 | |
| SCHEMBL19559666 | 0.71 | PPARG (0.46) | PPARGALDH1A1TP53MAPTMPC2 | |
| SCHEMBL19559652 | 0.71 | PPARG (0.40) | PPARGCYP3A4RXRAHRH3MAPT | |
| SCHEMBL19559724 | 0.70 | GLA (0.42) | PPARGSMN1; SMN2 | |
| SCHEMBL19559757 | 0.70 | PPARG (0.40) | PPARGCYP3A4RXRAHRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |