Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MPC2 | O95563 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559716 | 0.77 | PPARG (0.40) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL19217715 | 0.77 | PPARG (0.41) | PPARGHTTMPC2CYP2C8CYP2C9 | |
| SCHEMBL19217746 | 0.76 | PPARG (0.49) | PPARGMPC2CYP2C8CYP2C9CYP3A4 | |
| SCHEMBL19559701 | 0.75 | PPARG (0.51) | PPARGMPC2CYP2C8CYP2C9MCL1 | |
| SCHEMBL19559725 | 0.75 | PPARG (0.40) | PPARGCYP2C9MCL1CYP3A4CYP1A2 | |
| SCHEMBL19559715 | 0.72 | — | — | |
| SCHEMBL19217724 | 0.69 | PPARG (0.39) | PPARGHTTMPC2CYP2C8CYP2C9 | |
| SCHEMBL19559787 | 0.68 | PPARG (0.50) | PPARGMPC2CYP2C8CYP2C9MCL1 | |
| SCHEMBL19217761 | 0.68 | PPARG (0.68) | PPARGHTTMPC2CYP2C8CYP2C9 | |
| SCHEMBL19217752 | 0.67 | PPARG (0.52) | PPARGMPC2CYP2C8CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513070-B1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | CIRIUS THERAPEUTICS INC (US) | 2017-11-08 | — | — | EP | disclosed |