Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24093001 | 1.00 | BCHE (0.48) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL19568087 | 0.85 | POLB (0.59) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL24093028 | 0.85 | LOXL2 (0.46) | MEN1KMT2ARAB9AHRH3POLB | |
| SCHEMBL19567669 | 0.85 | POLB (0.59) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL24092992 | 0.85 | POLB (0.59) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL23514564 | 0.85 | LOXL2 (0.46) | MEN1KMT2ARAB9AHRH3POLB | |
| SCHEMBL24093082 | 0.84 | GRIN2B (0.54) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL1239998 | 0.83 | BCHE (0.61) | BCHEACHEBACE1MEN1KMT2A | |
| SCHEMBL19567514 | 0.83 | CARM1 (0.51) | BCHEACHEBACE1POLBJAK2 | |
| SCHEMBL19567373 | 0.83 | CARM1 (0.51) | BCHEACHEBACE1POLBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017191098-A1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-09 | — | — | WO | disclosed |