Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19567669 | 1.00 | POLB (0.59) | POLBACHEBCHEBACE1MEN1 | |
| SCHEMBL24092992 | 1.00 | POLB (0.59) | POLBACHEBCHEBACE1MEN1 | |
| SCHEMBL23514564 | 0.85 | LOXL2 (0.46) | POLBMEN1KMT2ARAB9AHRH3 | |
| SCHEMBL19567378 | 0.85 | BCHE (0.48) | POLBACHEBCHEBACE1MEN1 | |
| SCHEMBL24093001 | 0.85 | BCHE (0.48) | POLBACHEBCHEBACE1MEN1 | |
| SCHEMBL24093028 | 0.85 | LOXL2 (0.46) | POLBMEN1KMT2ARAB9AHRH3 | |
| SCHEMBL24093082 | 0.84 | GRIN2B (0.54) | ACHEBCHEBACE1MEN1KMT2A | |
| SCHEMBL3236686 | 0.83 | POLB (0.81) | POLBACHEBCHEBACE1MEN1 | |
| SCHEMBL24092981 | 0.82 | MEN1 (0.69) | ACHEBCHEBACE1MEN1KMT2A | |
| SCHEMBL11112228 | 0.77 | POLB (0.96) | POLBACHEBCHEBACE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017191098-A1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-11-09 | — | — | WO | disclosed |