Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23514564 | 1.00 | LOXL2 (0.46) | LOXL2KDM1AMAOAMAOBJAK2 | |
| SCHEMBL19650807 | 0.89 | LOXL2 (0.57) | LOXL2KDM1AMAOAMAOBJAK2 | |
| SCHEMBL24092992 | 0.85 | POLB (0.59) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL19567669 | 0.85 | POLB (0.59) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL19567378 | 0.85 | BCHE (0.48) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL19568087 | 0.85 | POLB (0.59) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL24093001 | 0.85 | BCHE (0.48) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL24093082 | 0.84 | GRIN2B (0.54) | MEN1RAB9AKMT2A | |
| SCHEMBL19568086 | 0.83 | MAOA (0.51) | KDM1AMAOAMAOBJAK2JAK1 | |
| SCHEMBL24092988 | 0.83 | MAOA (0.51) | KDM1AMAOAMAOBJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452464-B1 | PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |