Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569272 | 0.95 | PPARG (0.43) | ATF4GRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL19569304 | 0.94 | ATF4 (0.49) | ATF4ALDH1A1LMNATP53GAA | |
| SCHEMBL19569425 | 0.91 | ATF4 (0.51) | ATF4PPARGPPARDMAPT | |
| SCHEMBL30026263 | 0.91 | ATF4 (0.56) | ATF4 | |
| SCHEMBL20973901 | 0.91 | ATF4 (0.56) | ATF4 | |
| SCHEMBL19569276 | 0.87 | HTT (0.43) | ATF4GAAALOX12 | |
| SCHEMBL19569441 | 0.86 | ATF4 (0.50) | ATF4PPARGPPARD | |
| SCHEMBL19569296 | 0.85 | ATF4 (0.55) | ATF4 | |
| SCHEMBL30025127 | 0.85 | ATF4 (0.55) | ATF4 | |
| SCHEMBL20999043 | 0.84 | MAPT (0.42) | GRIN1GRIN2BALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |