Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569273 | 0.94 | ATF4 (0.44) | ATF4ALDH1A1LMNAGAANOTUM | |
| SCHEMBL19569272 | 0.93 | PPARG (0.43) | ATF4ALDH1A1LMNA | |
| SCHEMBL19569436 | 0.90 | ATF4 (0.56) | ATF4ALDH1A1LMNA | |
| SCHEMBL19569289 | 0.89 | ATF4 (0.64) | ATF4ALDH1A1LMNAGAATP53 | |
| SCHEMBL30024705 | 0.89 | ATF4 (0.64) | ATF4ALDH1A1LMNAGAATP53 | |
| SCHEMBL19569277 | 0.86 | HTT (0.44) | ATF4GAAALOX12 | |
| SCHEMBL19569276 | 0.85 | HTT (0.43) | ATF4GAAALOX12 | |
| SCHEMBL19569443 | 0.84 | ATF4 (0.60) | ATF4 | |
| SCHEMBL19569425 | 0.84 | ATF4 (0.51) | ATF4MAPT | |
| SCHEMBL20999053 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAGAANOTUMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |