Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ATF4 | P18848 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569273 | 0.95 | ATF4 (0.44) | PPARGPPARDATF4KDM4EGRIN1 | |
| SCHEMBL19569304 | 0.93 | ATF4 (0.49) | ATF4ALDH1A1LMNA | |
| SCHEMBL19569441 | 0.91 | ATF4 (0.50) | PPARGPPARDATF4 | |
| SCHEMBL19569296 | 0.91 | ATF4 (0.55) | ATF4 | |
| SCHEMBL30025127 | 0.91 | ATF4 (0.55) | ATF4 | |
| SCHEMBL19569425 | 0.86 | ATF4 (0.51) | PPARGPPARDATF4KMT2A | |
| SCHEMBL20973901 | 0.85 | ATF4 (0.56) | ATF4 | |
| SCHEMBL30026263 | 0.85 | ATF4 (0.56) | ATF4 | |
| SCHEMBL20999051 | 0.85 | ALDH1A1 (0.41) | PPARGPPARDALDH1A1LMNA | |
| SCHEMBL19569276 | 0.84 | HTT (0.43) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |