Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATF4 | P18848 | 10/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569469 | 0.87 | ATF4 (0.50) | ATF4MRGPRX4KMT2AMEN1NPY1R | |
| SCHEMBL30025703 | 0.87 | ATF4 (0.50) | ATF4MRGPRX4KMT2AMEN1NPY1R | |
| SCHEMBL19569204 | 0.79 | ATF4 (0.59) | ATF4KMT2AMEN1 | |
| SCHEMBL30024919 | 0.78 | ATF4 (0.48) | MAPTLMNAATF4KMT2AMEN1 | |
| SCHEMBL19569205 | 0.78 | ATF4 (0.48) | MAPTLMNAATF4KMT2AMEN1 | |
| SCHEMBL30026324 | 0.78 | ATF4 (0.55) | ATF4MRGPRX4 | |
| SCHEMBL19555442 | 0.78 | ATF4 (0.55) | ATF4MRGPRX4 | |
| SCHEMBL30025585 | 0.77 | ATF4 (0.53) | ATF4ALDH1A1 | |
| SCHEMBL19569461 | 0.77 | ATF4 (0.53) | ATF4ALDH1A1 | |
| SCHEMBL19569472 | 0.75 | ATF4 (0.43) | ATF4MRGPRX4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017193034-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |