Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.43 |
| ▸ | KDM5C | P41229 | 4/20 | 0.43 |
| ▸ | KDM4A | O75164 | 4/20 | 0.43 |
| ▸ | KDM5A | P29375 | 3/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4B | O94953 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20779104 | 0.90 | SIGMAR1 (0.43) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL15635975 | 0.83 | SIGMAR1 (0.58) | SIGMAR1USP2POLBGAA | |
| SCHEMBL15636850 | 0.76 | DRD4 (0.55) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL15636721 | 0.75 | SIGMAR1 (0.52) | KDM5BKDM5CKDM4AKDM6BSIGMAR1 | |
| SCHEMBL28168925 | 0.74 | SIGMAR1 (0.51) | SIGMAR1USP2POLBGAA | |
| SCHEMBL15636697 | 0.74 | KDM5C (0.48) | TSHRHSD17B10KDM5BKDM5CKDM4A | |
| SCHEMBL15637624 | 0.72 | MCHR1 (0.46) | KDM5BKDM5CKDM4AKDM5AKDM6B | |
| SCHEMBL15994202 | 0.72 | SIGMAR1 (0.59) | SIGMAR1USP2POLBGAA | |
| SCHEMBL16293099 | 0.72 | SIGMAR1 (0.47) | SIGMAR1CYP2D6CYP2C19SMN1; SMN2POLB | |
| SCHEMBL16293808 | 0.71 | SIGMAR1 (0.58) | SIGMAR1USP2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2017-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320827-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EHMT1, KDM1B, EHMT2 | TSHR 4436/4885HSD17B10 1487/4885KDM5B 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.