Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19574680 | 0.90 | TSHR (0.43) | SIGMAR1KDM5BKDM4AKDM6BKDM5A | |
| SCHEMBL15635975 | 0.86 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2AALDH1A1CCR8 | |
| SCHEMBL15636850 | 0.76 | DRD4 (0.55) | SIGMAR1KDM5BKDM4AKDM6BKDM5A | |
| SCHEMBL15636721 | 0.75 | SIGMAR1 (0.52) | SIGMAR1KDM5BKDM4AKDM6BKDM5C | |
| SCHEMBL28168925 | 0.75 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2AALDH1A1CCR8 | |
| SCHEMBL15636697 | 0.75 | KDM5C (0.48) | SIGMAR1MEN1KMT2AALDH1A1KDM5B | |
| SCHEMBL15994202 | 0.74 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2ACCR8GAA | |
| SCHEMBL16293808 | 0.74 | SIGMAR1 (0.58) | SIGMAR1MEN1KMT2ACCR8GAA | |
| SCHEMBL16006929 | 0.73 | SIGMAR1 (0.57) | SIGMAR1MEN1KMT2AL3MBTL1CCR8 | |
| SCHEMBL15637624 | 0.73 | MCHR1 (0.46) | SIGMAR1KDM5BKDM4AKDM6BKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221139-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221139-B2 | Inhibitors of histone demethylases | EHMT1, KDM1B, EHMT2 | SIGMAR1 3287/4885MEN1 4042/4885KMT2A 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.