Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19579982 | 0.90 | SLC34A2 (0.53) | SLC34A2TRPV1PPARGRAF1BRAF | |
| SCHEMBL19579991 | 0.89 | SLC34A2 (0.54) | SLC34A2CRHBPCRHR2TRPV1RAF1 | |
| SCHEMBL45535 | 0.88 | SLC34A2 (0.64) | SLC34A2TRPV1TLR9RAF1BRAF | |
| SCHEMBL19580034 | 0.88 | SLC34A2 (0.59) | SLC34A2TLR9RAF1BRAFKDM1A | |
| SCHEMBL19579993 | 0.88 | SLC34A2 (0.48) | SLC34A2PPARGKDM1AHDAC1 | |
| SCHEMBL19579951 | 0.88 | SLC34A2 (0.53) | SLC34A2TRPV1KDM1AHDAC1 | |
| SCHEMBL19580022 | 0.88 | SLC34A2 (0.50) | SLC34A2CRHBPCRHR2EPHX2PPARG | |
| SCHEMBL19580036 | 0.88 | SLC34A2 (0.48) | SLC34A2PPARGRAF1BRAFKDM1A | |
| SCHEMBL5999719 | 0.88 | SLC34A2 (0.65) | SLC34A2TRPV1TLR9RAF1BRAF | |
| SCHEMBL19579933 | 0.87 | SLC34A2 (0.56) | SLC34A2CRHBPCRHR2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | claimed |