Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19579983 | 0.90 | SLC34A2 (0.46) | SLC34A2LRRK2SMN1; SMN2MAPTNPC1 | |
| SCHEMBL19595685 | 0.89 | SLC34A2 (0.46) | SLC34A2LRRK2HDAC1SMN1; SMN2MAPT | |
| SCHEMBL39824 | 0.88 | SLC34A2 (0.44) | SLC34A2LRRK2HDAC1SMN1; SMN2MAPT | |
| SCHEMBL19579965 | 0.87 | SLC34A2 (0.47) | SLC34A2LRRK2HDAC1NPC1RAB9A | |
| SCHEMBL19580004 | 0.87 | SLC34A2 (0.52) | SLC34A2TRPV1HDAC1PARP1 | |
| SCHEMBL46435 | 0.87 | SLC34A2 (0.47) | SLC34A2HDAC1MAPTTP53LMNA | |
| SCHEMBL19579947 | 0.87 | SLC34A2 (0.53) | SLC34A2HDAC1SMYD2 | |
| SCHEMBL46677 | 0.87 | SLC34A2 (0.51) | SLC34A2 | |
| SCHEMBL40010 | 0.87 | SLC34A2 (0.39) | SLC34A2TRPV1LRRK2HDAC1SMN1; SMN2 | |
| SCHEMBL19579978 | 0.86 | SLC34A2 (0.51) | SLC34A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | claimed |