Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46762 | 0.94 | SLC34A2 (0.40) | SLC34A2LRRK2HDAC1PARP1MAPT | |
| SCHEMBL19579995 | 0.87 | SLC34A2 (0.43) | SLC34A2LRRK2HDAC1PARP1MAPT | |
| SCHEMBL19579983 | 0.86 | SLC34A2 (0.46) | SLC34A2LRRK2PARP1MAPTNPC1 | |
| SCHEMBL39824 | 0.85 | SLC34A2 (0.44) | SLC34A2LRRK2HDAC1PARP1MAPT | |
| SCHEMBL19595685 | 0.84 | SLC34A2 (0.46) | SLC34A2LRRK2HDAC1PARP1MAPT | |
| SCHEMBL15444418 | 0.83 | SLC34A2 (0.49) | SLC34A2MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19579965 | 0.82 | SLC34A2 (0.47) | SLC34A2LRRK2HDAC1PARP1NPC1 | |
| SCHEMBL19580004 | 0.82 | SLC34A2 (0.52) | SLC34A2HDAC1PARP1TRPV1 | |
| SCHEMBL46435 | 0.82 | SLC34A2 (0.47) | SLC34A2HDAC1MAPTTP53KDM4E | |
| SCHEMBL19579947 | 0.82 | SLC34A2 (0.53) | SLC34A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |