Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 6/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19579983 | 0.92 | SLC34A2 (0.46) | SLC34A2SIRT2SIRT1SIRT3PARP1 | |
| SCHEMBL19579947 | 0.90 | SLC34A2 (0.53) | SLC34A2HDAC1AURKARPS6KB1AURKB | |
| SCHEMBL19580004 | 0.90 | SLC34A2 (0.52) | SLC34A2HDAC1PARP1 | |
| SCHEMBL39824 | 0.90 | SLC34A2 (0.44) | SLC34A2HDAC1PARP1LRRK2NPC1 | |
| SCHEMBL46435 | 0.90 | SLC34A2 (0.47) | SLC34A2HDAC1TP53MAPT | |
| SCHEMBL19579995 | 0.89 | SLC34A2 (0.43) | SLC34A2HDAC1PARP1LRRK2NPC1 | |
| SCHEMBL19579965 | 0.89 | SLC34A2 (0.47) | SLC34A2HDAC1PARP1LRRK2NPC1 | |
| SCHEMBL15444403 | 0.89 | SLC34A2 (0.45) | SLC34A2SIRT2SIRT1SIRT3AURKA | |
| SCHEMBL19579993 | 0.89 | SLC34A2 (0.48) | SLC34A2HDAC1 | |
| SCHEMBL19579984 | 0.88 | SLC34A2 (0.46) | SLC34A2HDAC1IRAK4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |