Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502868 | 0.96 | HPGD (0.48) | SCN9AALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL1743409 | 0.86 | KDR (0.49) | SCN9AALDH1A1NPC1L3MBTL1MEN1 | |
| SCHEMBL1954871 | 0.81 | JAK2 (0.46) | ALDH1A1RAB9AHPGDNPC1L3MBTL1 | |
| SCHEMBL1744415 | 0.81 | KDR (0.52) | ALDH1A1RAB9AHPGDNPC1L3MBTL1 | |
| SCHEMBL1960348 | 0.78 | TSHR (0.50) | ALDH1A1RAB9AHPGDNPC1L3MBTL1 | |
| SCHEMBL367075 | 0.76 | TSHR (0.57) | ALDH1A1RAB9AHPGDNPC1L3MBTL1 | |
| SCHEMBL1957290 | 0.75 | KDM4E (0.49) | KDM4ELMNAHTTMEN1KMT2A | |
| SCHEMBL1955771 | 0.74 | HTR2A (0.52) | SCN9ATSHR | |
| SCHEMBL3498239 | 0.74 | THRA (0.46) | ALDH1A1RAB9AHPGDL3MBTL1LMNA | |
| SCHEMBL1742275 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1L3MBTL1KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507211-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068560-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |