SCHEMBL367075

SCHEMBL367075

CCOC(=O)c1ccc(F)cc1F

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.57
RAB9A P51151 2/20 0.55
CES2 O00748 1/20 0.55
CES1 P23141 1/20 0.55
ALDH1A1 P00352 1/20 0.55
CA12 O43570 2/20 0.53
CA1 P00915 2/20 0.53
CA2 P00918 2/20 0.53
CA7 P43166 2/20 0.53
CA9 Q16790 2/20 0.53
CA14 Q9ULX7 2/20 0.53
TDP1 Q9NUW8 3/20 0.52
POLB P06746 3/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
MAPT P10636 1/20 0.52
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
NPC1 O15118 2/20 0.52
GAA P10253 1/20 0.51
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4628672 0.87 TSHR (0.60) TSHRRAB9AALDH1A1CA12CA1
SCHEMBL23817389 0.87 RAB9A (0.50) TSHRRAB9ACES2CES1ALDH1A1
SCHEMBL1997075 0.86 TSHR (0.60) TSHRRAB9ACES2CES1ALDH1A1
SCHEMBL5247862 0.86 TSHR (0.57) TSHRRAB9AALDH1A1CA12CA1
SCHEMBL7222675 0.86 TSHR (0.53) TSHRRAB9AALDH1A1CA12CA1
SCHEMBL187298 0.84 CA12 (0.70) TSHRRAB9AALDH1A1CA12CA1
SCHEMBL11695717 0.84 TSHR (0.52) TSHRALDH1A1CA12CA1CA2
SCHEMBL927276 0.84 CA12 (0.70) TSHRALDH1A1CA12CA1CA2
SCHEMBL539982 0.83 MAP2K1 (0.55) TSHRALDH1A1CA12CA1CA2
SCHEMBL751617 0.83 LMNA (0.54) TSHRRAB9AALDH1A1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 298 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113429563-B Application of selective laser sintering by taking polyether-ether-ketone prepared by solvent as raw material 江汉大学 2023-05-23 CN claimed
CN-113429562-B Application of selective laser sintering by taking polyether-ether-ketone as raw material 江汉大学 2023-05-23 CN claimed
CN-113321800-B Application of selective laser sintering by taking polyether-ether-ketone prepared from tetramethyl guanidine tetrafluoroborate as raw material 江汉大学 2023-05-23 CN claimed
CN-113429532-B Application of polyether-ether-ketone prepared from 1-butyl-3-methylimidazole bromide in selective laser sintering 江汉大学 2023-05-23 CN claimed
CN-114865080-A Lithium ion battery electrolyte and lithium ion battery 香河昆仑新能源材料股份有限公司 2022-08-05 CN claimed
CN-113429562-A Application of selective laser sintering by taking polyether-ether-ketone as raw material 江汉大学 2021-09-24 CN claimed
CN-113429563-A Application of selective laser sintering by using polyether-ether-ketone prepared by adopting solvent as raw material 江汉大学 2021-09-24 CN claimed
CN-113429532-A Application of selective laser sintering by using polyether-ether-ketone prepared from 1-butyl-3-methylimidazole bromine salt as raw material 江汉大学 2021-09-24 CN claimed
CN-113321800-A Application of selective laser sintering by using polyether-ether-ketone prepared from tetramethylguanidine tetrafluoroborate as raw material 江汉大学 2021-08-31 CN claimed
CN-108034047-B Application of selective laser sintering by taking polyether-ether-ketone as raw material 江汉大学 2021-06-22 CN claimed
US-20170158666-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC (US) 2017-06-08 US claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
US-12577217-B2 15-PGDH inhibitor KYORIN PHARMACEUTICAL CO., LTD. (JP) 2026-03-17 US disclosed
US-20260028346-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 US disclosed
US-20260028345-A1 BTK DEGRADER AND USE THEREOF ASCENTAGE PHARMA SUZHOU CO LTD (CN) 2026-01-29 US disclosed
EP-4682148-A2 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES AbbVie Ireland Unlimited Company (IE) 2026-01-21 EP disclosed
US-5753682-A Imidazole lipoxygenase inhibitors PFIZER INC. (US) 1998-05-19 US disclosed
EP-0703913-B1 IMIDAZOLES AS LIPOXYGENASE INHIBITORS PFIZER (US) 1997-06-11 EP disclosed
EP-0703913-A1 IMIDAZOLE LIPOXYGENASE INHIBITORS PFIZER (US) 1996-04-03 EP disclosed
WO-1994029299-A1 IMIDAZOLE LIPOXYGENASE INHIBITORS PFIZER INC. (US) 1994-12-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028345-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, TEC TSHR 935/4885RAB9A 2655/4885CES2 2447/4885
US-12577217-B2 15-PGDH inhibitor PTGDR, ADH1A, ADRA1A TSHR 413/4885RAB9A 1847/4885CES2 1604/4885
US-20170158666-A1 APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES BCL2, BAX, BCL3 TSHR 3754/4885RAB9A 3546/4885CES2 4241/4885
US-20260028346-A1 BTK DEGRADER AND USE THEREOF BTK, SYK, LYN TSHR 1144/4885RAB9A 2415/4885CES2 2314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.