Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.42 |
| ▸ | ABAT | P80404 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 3/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | OAT | P04181 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19583108 | 1.00 | GABRR1 (0.42) | GABRR1ABATSLC6A12SLC6A11SLC6A13 | |
| SCHEMBL17714468 | 1.00 | GABRR1 (0.42) | GABRR1ABATSLC6A12SLC6A11SLC6A13 | |
| SCHEMBL1872031 | 0.83 | CYP2C19 (0.39) | GABRR1ABATCYP1A2ALOX15KDM4E | |
| SCHEMBL695096 | 0.77 | — | — | |
| SCHEMBL25530126 | 0.75 | CHRNB2 (0.40) | — | |
| SCHEMBL17723461 | 0.75 | CHRNB2 (0.40) | — | |
| SCHEMBL19583134 | 0.75 | CHRNB2 (0.40) | — | |
| SCHEMBL295283 | 0.75 | — | — | |
| SCHEMBL761864 | 0.75 | — | — | |
| SCHEMBL4287590 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180250282-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | LILLY CO ELI (US) | 2018-09-06 | — | — | US | disclosed |
| US-9962375-B2 | Methyl-piperidine compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-08 | — | — | US | disclosed |
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326128-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGER1 | GABRR1 495/4885ABAT 2052/4885SLC6A12 4284/4885 |
| US-20180250282-A1 | Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | PTGS1, PTGES, PTGER1 | GABRR1 488/4885ABAT 2165/4885SLC6A12 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.