Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479865 | 0.93 | CASP1 (0.49) | CASP1CTRB1CASP3 | |
| SCHEMBL2479868 | 0.93 | CASP1 (0.49) | CASP1CTRB1CASP3 | |
| SCHEMBL27850286 | 0.81 | ATM (0.46) | CTRB1 | |
| SCHEMBL8417460 | 0.78 | ALDH1A1 (0.49) | CTRB1 | |
| SCHEMBL2030179 | 0.78 | ALOX5 (0.44) | — | |
| SCHEMBL2481473 | 0.78 | ALOX5 (0.44) | — | |
| SCHEMBL3351265 | 0.78 | ALOX5 (0.44) | — | |
| SCHEMBL11475132 | 0.76 | ATM (0.53) | CTRB1HDAC3HDAC1HDAC2 | |
| SCHEMBL6955527 | 0.75 | CASP1 (0.60) | CASP1CTRB1 | |
| SCHEMBL6156731 | 0.75 | CASP1 (0.60) | CASP1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068561-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |