Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | IDE | P14735 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 6/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.46 |
| ▸ | BCR | P11274 | 5/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24943344 | 0.85 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL19592109 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1MAPK9MAPK10EGFR | |
| SCHEMBL19591992 | 0.80 | ROCK2 (0.64) | ROCK2ROCK1EGFR | |
| SCHEMBL19592078 | 0.79 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL19592079 | 0.78 | ROCK2 (0.63) | ROCK2ROCK1ABL1BCREGFR | |
| SCHEMBL17038111 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL24943925 | 0.74 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL28284095 | 0.73 | KMT2A (0.59) | KMT2AIDEBTKABL1PDGFRB | |
| SCHEMBL24943866 | 0.72 | ROCK2 (0.56) | ROCK2ROCK1 | |
| SCHEMBL18792356 | 0.71 | ROCK2 (0.66) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815820-B2 | Rho kinase inhibitors | KADMON CORPORATION, LLC (US) | 2017-11-14 | — | — | US | disclosed |