Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19592109 | 0.89 | ROCK2 (0.64) | ROCK2ROCK1JAK2EGFRMAPK14 | |
| SCHEMBL23380752 | 0.86 | ROCK2 (0.66) | ROCK2ROCK1RAB9AEGFR | |
| SCHEMBL19591992 | 0.84 | ROCK2 (0.64) | ROCK2ROCK1CDK2ATREGFR | |
| SCHEMBL19592078 | 0.80 | ROCK2 (0.66) | ROCK2ROCK1CDK2ATRDHODH | |
| SCHEMBL19592018 | 0.78 | ROCK2 (0.63) | ROCK2ROCK1ABL1BCRALDH1A1 | |
| SCHEMBL17038109 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL28227359 | 0.74 | ROCK2 (0.61) | ROCK2ROCK1PLK4JAK2FLT3 | |
| SCHEMBL18792356 | 0.72 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL24943925 | 0.71 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL23906216 | 0.69 | CCNT1 (0.59) | ROCK2KDM4ERAB9AFLT3CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815820-B2 | Rho kinase inhibitors | KADMON CORPORATION, LLC (US) | 2017-11-14 | — | — | US | disclosed |