Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.48 |
| ▸ | CDK2 | P24941 | 8/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19591992 | 0.90 | ROCK2 (0.64) | ROCK2ROCK1CCNE1CDK2ATR | |
| SCHEMBL19592109 | 0.82 | ROCK2 (0.64) | ROCK2ROCK1 | |
| SCHEMBL19592079 | 0.80 | ROCK2 (0.63) | ROCK2ROCK1CDK2ATRDHODH | |
| SCHEMBL17041185 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL19592018 | 0.79 | ROCK2 (0.63) | ROCK2ROCK1 | |
| SCHEMBL17038115 | 0.79 | ROCK2 (0.67) | ROCK2ROCK1CCNE1CDK2ATR | |
| SCHEMBL18792356 | 0.79 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL23380752 | 0.73 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL24943925 | 0.71 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL15639810 | 0.71 | ROCK2 (0.84) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815820-B2 | Rho kinase inhibitors | KADMON CORPORATION, LLC (US) | 2017-11-14 | — | — | US | disclosed |