Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862643 | 0.91 | ROCK2 (0.57) | ROCK2ROCK1SLC2A3 | |
| SCHEMBL24862663 | 0.85 | ROCK2 (0.64) | ROCK2ROCK1 | |
| SCHEMBL24862273 | 0.85 | ROCK2 (0.55) | ROCK2ROCK1MAPTEGFR | |
| SCHEMBL24862319 | 0.83 | ROCK2 (0.47) | ROCK2ROCK1 | |
| SCHEMBL24353607 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1SLC2A3 | |
| SCHEMBL24464157 | 0.82 | ROCK2 (0.66) | ROCK2ROCK1SLC2A3 | |
| SCHEMBL17038112 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20661285 | 0.81 | ROCK2 (0.67) | ROCK2ROCK1EGFRJAK3 | |
| SCHEMBL17038101 | 0.81 | ROCK2 (0.68) | ROCK2ROCK1SLC2A3 | |
| SCHEMBL23380752 | 0.79 | ROCK2 (0.66) | ROCK2ROCK1FKBP1AMAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116293-A2 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |
| US-9815820-B2 | Rho kinase inhibitors | KADMON CORPORATION, LLC (US) | 2017-11-14 | — | — | US | disclosed |