Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 11/20 | 0.38 |
| ▸ | CA1 | P00915 | 10/20 | 0.38 |
| ▸ | CA12 | O43570 | 8/20 | 0.38 |
| ▸ | CA9 | Q16790 | 8/20 | 0.38 |
| ▸ | CA4 | P22748 | 7/20 | 0.38 |
| ▸ | CA6 | P23280 | 7/20 | 0.38 |
| ▸ | CA7 | P43166 | 7/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 7/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 7/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 6/20 | 0.38 |
| ▸ | CA3 | P07451 | 5/20 | 0.38 |
| ▸ | CA5A | P35218 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700042 | 0.97 | ENPP2 (0.41) | ENPP2CA2CA1CA12CA9 | |
| SCHEMBL1700045 | 0.76 | CA2 (0.42) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1700160 | 0.74 | CA2 (0.44) | ENPP2CA2CA1CA12CA9 | |
| SCHEMBL1700343 | 0.73 | PTGS1 (0.43) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1699945 | 0.73 | CA1 (0.57) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1959351 | 0.71 | SCN5A (0.48) | CA2CA1P2RX4PTGES2CISD1 | |
| SCHEMBL1700396 | 0.69 | ALDH1A1 (0.42) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1700044 | 0.68 | SCN5A (0.49) | CA2CA1CA6CA7CA5B | |
| SCHEMBL2483132 | 0.67 | HSP90AA1 (0.34) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1700199 | 0.67 | HTT (0.47) | CA2CA1CA12CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507229-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068561-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |